Dana-Farber's Giacomo Oliveira, PhD describes a study he led with Cathy Wu, MD, that appeared in Nature . The study led to the identification of the properties of antitumor T cells and highlight how such findings can pave the road to the development of novel therapeutic strategies that aim at generating T cells with potent antitumor TCRs and functional cell states.
a major issue in the field of cancer immunotherapy is to try to understand what are the properties and the type of anti human T cells so that we can better design new therapeutic approaches that at least it enforced it with their activity of such anti human T cells against cancer cells. And unfortunately this is not an easy task. And since within the body any particular within the human micro environment there are many other cities are not specific for the. And in the lab of cutting we wanted to uh really capture the final tax and the properties of the Truth 2026. And we talk on this issue by combining the high resolution profiling of the T cells into trading Manorama specimens with the study of the multiple that drives the ability of the details to recognize into your concerts. The so called tea set Aceptar for DCR. And in the majority of the patient an alliance that we could identify strong anti to notice uh cr they were able to recognize different human condition such as uh anonymous society orientation which are proteins that are expressed over, expressed about humans or personal nuances that are you did it brought in that are produced as a result of human mutations and by patient PCP a few months. And regardless of the ambition specificity we could also that the majority of the PcR uh specific for the humor were expressed by South in a dysfunctional state known as exhaustion. So we can observe that within the two more uh the strong entity more specificity the art for the vast majority coupled with dysfunction ourselves state. But our work provides also known as the path to isolate such strong and most precipice, difficult couple exhaustion and design new therapeutic approaches that now couple and disentangle these two aspect of the T cell biology. By transferring the information of the strong, anti traumatised uh the CR insults with better for genotype to achieve a stronger anti tumor activity.
