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SABCS 2022: Sara Tolaney, MD, MPH
Updated data from the APT trial shows that after 10 years of follow-up, adjuvant paclitaxel and trastuzumab confirm excellent long-term outcomes for small, node-negative HER2-positive breast cancer.
Video
SABCS 2022: Paolo Tarantino, MD
ATEMPT study shows that 5 years after treatment, 97% of patient's w/stage 1 HER2+ breast cancer treated w/TDM1 were alive and free from invasive disease and 98.3% had no recurrence of their cancer.
Video
SABCS 2022: Ann Partridge, MD, MPH
Ann Partridge, MD, MPH, led the study presented at the 2022 San Antonio Breast Cancer Symposium which showed most women participating in the study went on to deliver healthy babies.
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SABCS 2022: Rachel Freedman, MD, MPH
Rachel Freedman, MD, MPH, shared results from the TBCRC 022 study where Neratinib in combination w/T-DM1 showed promising activity in patients w/heavily pre-treated HER2+ breast cancer metastatic to the central nervous system.
News
Study Finds That Risk of Adverse Side Effects From Cancer Immunotherapy is Higher in Patients with Certain Inherited Genetic Variations
Even as they've revolutionized cancer treatment, drugs known as immune checkpoint inhibitors can produce a range of adverse, immune-related side effects. In a new study, scientists at Dana-Farber Cancer Institute identify, for the first time, inherited genetic variations that place patients at high risk for these complications.
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Dana-Farber Research Publication 12.15.2021
This twice-monthly newsletter highlights the research endeavors at Dana-Farber Cancer Institute, noting recently published papers available from PubMed where Dana-Farber faculty are listed as first or senior authors.
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Next-Generation Drug Improves Progression-Free Survival in Relapsed Chronic Lymphocytic Leukemia
A head-to-head clinical trial in patients with relapsed or refractory chronic lymphocytic leukemia (CLL) and small lymphocytic lymphoma (SLL) has found that zanubrutinib, a next-generation BTK inhibitor, was more effective at preventing disease progression and better tolerated than ibrutinib, the first-generation BTK inhibitor that is the current standard treatment in that setting.
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New Clinical Tool for Clonal Hematopoiesis Identifies Patients at High Risk for Blood Cancer
Clonal hematopoiesis (CH) is a recently characterized condition in which the genetic mutations associated with leukemia and other blood cancers are found in the blood of individuals without cancer. This pre-cancerous state is fairly common — for example, it’s present in roughly 15% of people over age 65 — but only a small percentage, around 4%, will go on to develop blood cancer.
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CAR-T-Cell Shows Promise in Patients with Lymphoma of the Brain and Spinal Cord in Early Trial
A CAR-T-cell therapy known as axicabtagene ciloleucel (axi-cel) is safe and shows encouraging signs of efficacy in a small pilot trial involving patients with lymphoma of the brain and/or spinal cord, Dana-Farber Cancer Institute investigators report at the 64th American Society of Hematology (ASH) Annual Meeting.
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Scientists Map Genetic Evolution of Chronic Lymphocytic Leukemia to Richter's Syndrome
Every year, up to 1% of patients with chronic lymphocytic leukemia (CLL), a slow-growing blood cancer, have their disease transform into a far more aggressive cancer, a form of lymphoma known as Richter's Syndrome. For the most part, the genomic changes that underlie this metamorphosis and push it forward have been obscure, hindering advances in treatment.
Symposium
2022 SABCS Highlights
Review highlights from the 45th annual San Antonio Breast Cancer Symposium. December 6 - 10, 2022.
Document
Breast Oncology Research Presentations Schedule
The 45th annual San Antonio Breast Cancer Symposium. December 6 - 10, 2022