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Season 2, Episode 2: Thalidomide and its Second Act in Multiple Myeloma
Momentum isn't always one way. And it's not always constant. Sometimes it shoves you sideways, sometimes it stops you in your tracks. And sometimes only sometimes, it drives you to write one of the most astonishing second acts in all of medicine. That's the story of thalidomide.
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Study Suggests Possible Way to ‘Smac’ Cancer
In a new study, researchers at Dana-Farber Cancer Institute used cryo-electron microscopy to reveal for the first time how one IAP, a protein called BIRC6, operates at a molecular level to inhibit programmed cell death.
Podcast
Season 2, Episode 1: BCL-2 Inhibitors: Driving Cells to Destruction
The story begins decades ago with a man named Stanley Korsmeyer, who led the molecular oncology program at Dana-Farber from 1998 until his death in 2005. He discovered that B cell cancers like CLL over-produced a protein called Bcl-2, and interfered with apoptosis, or programmed cell death. But how that went from an interesting discovery to a game-
Video
Smoldering Multiple Myeloma - A Unique New Approach
When Deidre was diagnosed with a precursor condition to multiple myeloma she enrolled in a brand-new clinical trial being conducted at Dana-Farber Cancer Institute. Deidre and her doctor, Dana-Farber's Irene Ghobrial, MD, explain more in this video.
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Dana-Farber Research Supports FDA Approval of New Therapy for Metastatic Breast Cancer
Sacituzumab govitecan, a novel antibody drug-conjugate therapy has been granted accelerated approved by the U.S. Food and Drug Administration (FDA) for the treatment of metastatic HR+, HER2- breast cancer.
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Dana-Farber Researcher Awarded Victoria Mock New Investigator Award
Rachel Pozzar, PhD, RN, a nurse scientist in the Phyllis F. Cantor Center for Research in Nursing and Patient Care Services at Dana-Farber Cancer Institute and an instructor in medicine at Harvard Medical School, has been awarded the 2023 Oncology Nursing Society’s (ONS) Victoria Mock New Investigator Award.
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Dana-Farber Research Publication 02.01.2023
This twice-monthly newsletter highlights the research endeavors at Dana-Farber Cancer Institute, noting recently published papers available from PubMed where Dana-Farber faculty are listed as first or senior authors.
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Dana-Farber Led Study Leads to FDA Approval for Next-Generation Drug in Relapsed Chronic Lymphocytic Leukemia
On Thursday, January 19, 2023, the FDA approved zanubrutinib, a next-generation BTK inhibitor for the treatment of patients with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL).
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Study Links Key Activating Enzymes to Specific Sites on Proteins in Cells
Thousands of proteins in a human cell are regulated by phosphorylation -- the addition of small chemical groups to the proteins’ amino acids by enzymes called protein kinases.
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More Than 120 Dana-Farber Affiliated Faculty Named as 2023 Top Doctors in Boston Magazine
Boston magazine has named more than 120 physicians affiliated with Dana-Farber Cancer Institute to its annual "Top Doctors" guide.
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Immunotherapy With Two Novel Drugs Shows Activity in Colorectal Cancer
A combination of two next-generation immunotherapy drugs has shown promising clinical activity in treating patients with refractory metastatic colorectal cancer, a disease which has not previously responded well to immunotherapies, according to a Dana-Farber Cancer Institute researcher.
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Molecular Tumor Board Provides Useful Assist in Cancer Precision Medicine
The field of precision cancer medicine has become so complex that even experienced oncologists can find it challenging to decipher the results of molecular tests of tumor tissue and navigate treatment options for patients. At Dana-Farber Cancer Institute, a multi-disciplinary team has been assisting gastrointestinal cancer physicians – reviewing test results and offering timely recommendations on treatment options.